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We have recently experienced some technical issues that affected a number of our systems, including those used to publish articles. We believe that we have rectified the issue and are now resuming publication.
However, because we were unable to publish for a time, there will be some delay in publishing anything new while we get the backlog cleared.
We are working hard to get back up to date, and thank you in advance for your patience if things take a little longer than usual. Microbial contamination is a serious challenge that needs to be overcome for the successful biosynthesis of 2,3-butanediol 2,3-BD.
However, traditional strategies such as antibiotic administration or sterilization are costly, have high energy demands, and may increase the risk of antibiotic resistance.
Here, we intend to develop a robust strategy to achieve non-sterilized fermentation of 2,3-BD. Briefly, the robust strain can metabolize unconventional chemicals as essential growth nutrients, and therefore, outcompete contaminant microbes that cannot use unconventional chemicals.
To this end, Klebsiella pneumoniae OU7, a robust strain, was confirmed to rapidly exploit urea and phosphite unconventional chemicals as the primary sources of nitrogen N and phosphorus P , and withstand deliberate contamination in the possibly contaminated systems.
Secondly, metabolic engineering, pathogenicity elimination and adaptive laboratory evolution were successively performed, endowing the best strain with an excellent fermentation performance for safe 2,3-BD production.
Finally, In summary, our technique reduces labor and energy costs and simplifies the fermentation process because sterilization does not need to be performed.
Thus, our work will be beneficial for the sustainable synthesis of 2,3-BD. If you are not the author of this article and you wish to reproduce material from it in a third party non-RSC publication you must formally request permission using Copyright Clearance Center.
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Mit Google übersetzen. Ergebnisse: Befriedigend 0. As a member of the wwPDB, the RCSB PDB curates and annotates PDB data according to agreed upon standards. The RCSB PDB also provides a variety of tools and resources. Users can perform simple and advanced searches based on annotations relating to sequence, structure and function. These molecules are visualized, downloaded, and analyzed by users who range from students to specialized scientists. OU7 7-{3-(aminomethyl)[(1,3-thiazolyl)methoxy]phenyl}methylquinolinamine. Find entries where: OU7 is present as a standalone ligand. OU7 as a non-polymer is covalently linked to polymer or other heterogen groups. OU7 is present in a polymer sequence. Find related ligands. To this end, Klebsiella pneumoniae OU7, a robust strain, was confirmed to rapidly exploit urea and phosphite (unconventional chemicals) as the primary sources of nitrogen (N) and phosphorus (P), and withstand deliberate contamination in the possibly contaminated systems. Secondly, metabolic engineering, pathogenicity elimination and adaptive Author: Ze-Wang Guo, Xiao-Yang Ou, Pei Xu, Hui-Fang Gao, Liao-Yuan Zhang, Min-Hua Zong, Wen-Yong Lou.
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Dies Ou7 schon die hohen Limits der Ou7 immer wieder unter Beweis. - Stöbern in Kategorien
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